%PDF-1.4
%
88 0 obj
<>
endobj
85 0 obj
<>stream
Acrobat Distiller 8.1.0 (Windows)
Arbortext Advanced Print Publisher 10.0.1465/W Unicode
2015-12-08T00:55:15-08:00
2015-11-25T09:56:52+05:30
2015-12-08T00:55:15-08:00
application/pdf
YantGAD271072 2405..2419
uuid:67b68133-72e6-4557-b7d8-1ad57e044376
uuid:63b199ea-1dd2-11b2-0a00-0cf6385afdff
endstream
endobj
89 0 obj
<>
endobj
77 0 obj
<>
endobj
79 0 obj
<>
endobj
80 0 obj
<>
endobj
81 0 obj
<>
endobj
52 0 obj
<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
54 0 obj
<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
56 0 obj
<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
61 0 obj
<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
63 0 obj
<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
131 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
148 0 obj
[155 0 R 156 0 R 157 0 R 158 0 R 159 0 R 160 0 R 161 0 R 162 0 R 163 0 R 164 0 R]
endobj
149 0 obj
<>stream
q
287.5 0 0 75 160.75 681 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
10 0 0 10 332.15976 582.99982 Tm
( )Tj
0 0 1 rg
-11.12 0 Td
(10.1101/gad.271072.115)Tj
0 g
-16.89598 0 Td
(Access the most recent version at doi:)Tj
5.28 1 Td
( 2015 29: 2405-2419 )Tj
/T1_1 1 Tf
-5.28 0 Td
(Genes Dev.)Tj
/T1_0 1 Tf
0 1.00001 TD
(\240 )Tj
0 1 TD
(Levi Yant and Kirsten Bomblies)Tj
T*
(\240 )Tj
/T1_2 1 Tf
15 0 0 15 52 632.99997 Tm
(and challenges of whole-genome duplication)Tj
21.76994 1 Td
(cell-level opportunities)Tj
/T1_3 1 Tf
-1.09799 0 Td
(--)Tj
/T1_2 1 Tf
-20.67195 0 Td
(Genome management and mismanagement)Tj
ET
52 571 m
557 571 l
0 0 m
S
BT
ET
BT
/T1_0 1 Tf
11 0 0 11 142.94202 539.99997 Tm
(\240 )Tj
/T1_2 1 Tf
-5.11299 1 Td
(References)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 163 531.99994 Tm
(\240 )Tj
30.00783 1 Td
( )Tj
0 0 1 rg
/T1_2 1 Tf
-30.00783 0 Td
(http://genesdev.cshlp.org/content/29/23/2405.full.html#ref-list-1)Tj
0 g
/T1_0 1 Tf
0 1.00001 TD
(This article cites 180 articles, 48 of which can be accessed free at:)Tj
ET
BT
/T1_0 1 Tf
11 0 0 11 144.94208 483.99991 Tm
(\240 )Tj
/T1_2 1 Tf
-3.44598 1 Td
(License)Tj
-1.16501 1.00001 Td
(Commons )Tj
0.94299 1 Td
(Creative)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 380.30963 477.99988 Tm
(.)Tj
0 0 1 rg
-20.61896 0 Td
(http://creativecommons.org/licenses/by-nc/4.0/)Tj
0 g
-1.112 0 Td
(at )Tj
0 1 TD
(Creative Commons License \(Attribution-NonCommercial 4.0 International\)\
, as described )Tj
20.78496 1.00001 Td
(\). After six months, it is available under a)Tj
0 0 1 rg
-20.78496 0 Td
(http://genesdev.cshlp.org/site/misc/terms.xhtml)Tj
0 g
T*
(six months after the full-issue publication date \(see )Tj
T*
(This article is distributed exclusively by Cold Spring Harbor Laboratory\
Press for the first)Tj
ET
BT
/T1_2 1 Tf
11 0 0 11 108.86192 442.99997 Tm
(Service)Tj
-3.16599 1 Td
(Email Alerting)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 334.18964 444.99997 Tm
( )Tj
0 0 1 rg
/T1_2 1 Tf
-4.892 0 Td
(click here.)Tj
0 g
/T1_0 1 Tf
-12.22696 0 Td
(right corner of the article or)Tj
T*
(Receive free email alerts when new articles cite this article - sign up \
in the box at the top)Tj
ET
52 426 m
557 426 l
0 0 m
S
BT
ET
BT
/T1_2 1 Tf
11 0 0 11 86.71036 389.99997 Tm
(Collections)Tj
2.72299 1 Td
(Topic)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 173 371.99991 Tm
(\240 )Tj
14.61501 1 Td
( \(51 articles\))Tj
0 0 1 rg
-14.61501 0 Td
(\240 Cell Cycle and DNA Replication)Tj
0 g
0 1.00001 TD
(\240 )Tj
0 1 TD
(Articles on similar topics can be found in the following collections )Tj
ET
52 353 m
557 353 l
0 0 m
S
BT
ET
q
468 0 0 60 70.5 159 cm
-1 TL /Im1 Do
Q
52 119 m
557 119 l
0 0 m
S
BT
ET
BT
/T1_2 1 Tf
10 0 0 10 242.03882 83.99997 Tm
( )Tj
0 0 1 rg
-19.00388 0 Td
(http://genesdev.cshlp.org/subscriptions)Tj
0 g
/T1_0 1 Tf
9 0 0 9 209.06783 94 Tm
(go to: )Tj
/T1_1 1 Tf
-10.338 0 Td
(Genes & Development )Tj
/T1_0 1 Tf
-7.11398 0 Td
(To subscribe to )Tj
ET
52 68 m
557 68 l
0 0 m
S
BT
ET
BT
/T1_0 1 Tf
10 0 0 10 54 42 Tm
(\251 2015 Yant and Bomblies; Published by Cold Spring Harbor Laboratory \
Press)Tj
ET
BT
/T1_0 1 Tf
8 0 0 8 506.08368 779 Tm
( )Tj
0 0 1 rg
-16.44997 0 Td
(Cold Spring Harbor Laboratory Press)Tj
0 g
-16.78598 0 Td
( on December 8, 2015 - Published by )Tj
0 0 1 rg
-8.67099 0 Td
(genesdev.cshlp.org)Tj
0 g
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
153 0 obj
<>/Filter/FlateDecode/Height 300/Length 73148/Name/X/Subtype/Image/Type/XObject/Width 1150>>stream
HypqlJjBa
80@bA
"pRHB)CSJP(M`*jQC`Ӻ\=}Oaq'ٍ3~?ly|`# @$)/ 0 " H (/ 4W~kU7oU\EQykY-&M͛5n爋sƆ) P^ ~P\g.~ٿ[_ShԂAxgE_Kfm۴H~mn:o ԂQqٹr?_e0+Ey
5UTf-6کc% (/
孍+*}m6F}X־]==hz* @h(/
ٕk:l6Nϧ#;̙9/? |6n.t&~Ov11֗fڳ~O Aj+XtG6yROE| ylž>t8Jd.Mָ<
/rO x @ue{m6SD._>Q{DY D'VNNU5A'jl6fOIJl' ܃M~`sX:-jZ07(":6dh4 P/(/ Ѵwcy